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Organic Synthesis (Oxford Chemistry Primers), by Christine L. Willis, Martin Wills
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This practical book uses a wide range of examples in a versatile approach to the design of effective syntheses. Retrosynthetic analysis--a method of identifying simple starting materials for a synthesis--is introduced with emphasis on the importance of bond polarity and functional group interconversions. The next section discusses how an effective route to a target molecule containing more than one functional group can be followed, while later chapters review methods for the control of chemo-, regio-, and stereoselectivity, and include a discussion of protecting groups. Finally, four syntheses of pyrrolidine alkaloids are compared using previously described principles.
- Sales Rank: #457812 in Books
- Published on: 1996-01-18
- Original language: English
- Number of items: 1
- Dimensions: 7.20" h x .20" w x 9.40" l, .50 pounds
- Binding: Paperback
- 96 pages
Review
`Any book that highlights the elegance of organic sythesis and gives a rational approach to the art will surely be welcomed with open arms; this is such a book.'
Chemistry in Britain, March 1996
`A gentle introduction to the subject'
Peter Budd, University of Manchester, New Scientist, March 1997
From the Back Cover
This series of short texts provides accessible accounts of a range of essential topics in chemistry. Written with the needs of the student in mind, the Oxford Chemistry Primers offer just the right level of detail for undergraduate study, and will be invaluable as a source of material commonly presented in lecture courses yet not adequately covered in existing texts. All the basic principles and facts in a particular area are presented in a clear and straightforward style, to produce concise yet comprehensive accounts of topics covered in both core and specialist courses. This book introduces a logical approach for the design of synthetic routes to reasonably complex organic molecules from simple starting materials. It describes the concept of 'retrosynthesis', which allows suitable simple starting materials to be identified; the importance of bond polarity and functional group interconversions; how to find an effective route to a target molecule containing more than one functional group; and valuable strategies to adopt when designing syntheses. The text also includes a review of methods for the control of chemo-, regio-, and stereoselectivity, and a discussion of protecting groups. Finally four syntheses of the pyrrolidine alkaloids are compared and contrasted using the principles described in the book. Practice examples are provided throughout the book.
About the Author
Chris Willis and Martin Wills are both at the University of Bath.
Most helpful customer reviews
3 of 3 people found the following review helpful.
91-Page small masterpiece on a large topic
By Hongyi Wang
Like many other items in this Oxford chemistry primers, this one is of particlar value among those heavy big volumes on this topic. As precise as it could be - 91 pages, it has covered all the major points of organic synthesis in terms of retrosynthesis analysis and selectivity, as well as representative published works. The authors also pay attention to touch on different reactions as many as possible - after all mastering reactions is a must for successful synthesis. The best feature is the logical presentation of the topic which allows the readers to actually enjoy reading without much difficulty - with gradual increase of depth to the final original publications. Of course such a volume is not intended for those who are very experienced in the art of organic synthesis. Rather, it could be very refreshing and helpful for the experienced ones to pick up this topic again after a while away from this field. Or it could serve as a valuable piece for an organic chemistry student prior to formal graduate level organic synthesis. Or test yourself if you understand all the material in this book - if the answer is yes, you should be a proud synthetic organic chemist already!
1 of 1 people found the following review helpful.
An amazing guide to retrosynthesis
By DCB
If you are struggling with organic chemistry, do yourself a favor and buy this primer! It helps with understanding the fundamentals of synthesis and will give you a much needed understanding on how to put together molecules.
1 of 1 people found the following review helpful.
Excellent
By :)
This book is excellent. It's college level chemistry but it might be good for some high school students with an interest in chemistry.
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